Antidiabetic activity of Peristrophe bicalyculata leaves extract in Streptozotocin, and Alloxan-induced diabetic rats

Effects of Peristrophe bicalyculata methanol extract in Type 1 diabetic rats

  • Ezekiel Olugbenga Iwalewa Professor
  • ADEDAMOLA ADEGBITE Mrs
  • GRACE O FAKUNLE
  • JERRY AWME
  • ADURAGBENRO DEBBY ADEADPO
  • MARY OLUFUNMILAYO OLOGE
  • OLASUBOMI SOTUNDE
  • BABATUNDE ALABI
  • SIMEON KOLA ADESINA, prof

Abstract

The present study was designed to investigate the antidiabetic and antihyperlipidemic effect of Peristrophe bicalyculata leaves extract in Wistar rats. Streptozotocin and alloxan were used to induce type 1 diabetes or chemically-induced diabetes. In each experiment, forty-nine albino rats (120 – 150 g) were divided into 7 groups (n=7). Rats in group A (Control) and B (Diabetic control) were administered 0.2ml/day of distilled water. Group C rats were administered Glibenclamide (5 mg/kg, oral). Rats in group D (non-diabetic rats), E, F and G were administered P. bicalyculata methanol extract (400, 100, 200 and 400 mg/kg body weight) orally respectively for 1 week.  Evaluation of fasting blood glucose level, lipid profiling, and adiponectin levels were carried out. Fasting blood glucose levels and plasma lipid profiles of diabetic control rats were significantly higher than those of normal control rats. Administration of 100, 200 and 400 mg/kg methanol extract of P. bicalyculata significantly reduced blood glucose level when compared to diabetic control after one week (168 hours). At 100 mg/kg of P. bicalyculata extract (specifically), the serum level of low density lipoprotein cholesterol was reduced and that of high density lipoprotein cholesterol was enhanced compared to diabetic control (p<0.05). The serum level of triglyceride and very low density lipoprotein was reduced. At 400 mg/kg concentration, there was a significant reduction in serum total cholesterol level. Results also revealed that 100 mg/kg leaves extract significantly increased adiponectin levels in pre-treated diabetic rats compared to non-treated diabetic rats.

 

References

Abdulazeez Mansurah, (2011). Effect of Peristrophe bicalyculata on lipid profile of P- 407-induced hyperlipidemic Wistar rats. Journal of Medicinal Plants Research. 5(4): 490-494.
American Diabetes Association (2016). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 35: S13-S22.
Anna V. Goropashnaya, Johanna Herron, Mary Sexton, Peter J. Havel (2009). Relationship between plasma adiponectin and body fat distribution insulin sensitivity and plasma lipoprotieins in Alaskan Yup ‘ik Eskimos. Metabolism. 58(1): 22–29.
Arunkumar E. Achari and Sushil K. Jain (2017) Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction International Journal of Molecular Sciences. 18(6): 1321- 1338
Chen J, Tan B, Karteris E, Zervou S, Digby J, Hillhouse EW, Vatish M, Randeva HS (2006). "Secretion of adiponectin by human placenta: differential modulation of adiponectin and its
receptors by cytokines". Diabetologia. 49 (6): 1292–302.
Choudhury, Hira; Manisha Pandey, Chua Kui Hua, Cheah Shi Mun Jessmie Koh Jing, et al; (2018) An update on natural compounds in the remedy of diabetes mellitus: A systematic review Journal Traditional Complementary Medicine. 8(3): 361–376.
Coppola A, Marfella R, Coppola L, Tagliamonte E, Fontana D, Liguori E, Cirillo T, Cafiero M, Natale S, Astarita C (2009). "Effect of weight loss on coronary circulation and adiponectin levels in obese women". International Journal of Cardiology. 134 (3): 414–6
Dale S. Edgerton, Christopher J. Ramnanan, Carrie A. Grueter (2009). Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In-Vivo. American Diabetes Association. 58(12): 2766–2775.
Díez J.J, Iglesias P (2003). "The role of the novel adipocyte-derived hormone adiponectin in human disease". European Journal of Endocrinology. 148 (3): 293–300.
Dresden, Danielle, (2017). "Effects of diabetes on the body and organs." Medical News Today. MediLexicon, Intl. Web.
Friedewald WT, Levy RI, Fredrickson DS, (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem.18:499-502.
Gamaleldin I. Harisa, Fars K. Alanazi (2014). Low density lipoprotein bionanoparticle: From cholesterol transport to delivery of anticancer drugs. Saudi Pharm J. 22(6): 504–515.
Gaudani Rashmi, Patel Jaya, Prajapati Hardik (2010). Peristrophe bicalyculata - A Review. Pharmacognosy Journal. 2: 39-45.
Ghorban Mohammadzadeh, Mohammad-Ali Ghaffari, (2014). Additional effect of diabetes mellitus type 2 on the risk of coronary artery disease: Role of serum adiponectin. Iran Red Crescent Med J. 16(1): e8742
Hoda S., Mohammad A., Afaq S.H. and Tajuddin, (2006). Pharmacological Studies of “Chaksini” (Peristrophe bicalyculata Nees) in relation to Psychosomatic Disorders. Hamdard Medicus. 49(1): 116-119.
International Diabetes Federation. (2013). Diabetes Atlas 6th Edition, Chapter 2, 29-49.
Janine K Kruit, Albert K Groen, Theo J van Berkel, Folkert Kuipers, (2006). Emerging role of the intestine in control of cholesterol metabolism. World J Gastroenterol. 12(40): 6429–6439.
Kazeem M. I., J. O. Adamson and Ogunwande I. A., (2013). Modes of Inhibition of α-Amylase and α-Glucosidase by Aqueous Extract of Morinda lucida Benth Leaf. Biomed Res Int. 2013: 527570.
Klaus G. Parhofer, (2015). Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia. Diabetes Metab J.39(5): 353–362.
Kodl C T. and. Seaquist E. R (2008). Cognitive Dysfunction and Diabetes Mellitus. Endocrine Review. 29 (4): 494–511.
Kooti, Wesam, Maryam Farokhipour, Zahra Asadzadeh, Damoon Ashtary-Larky, and Majid Asadi-Samani (2016). The role of medicinal plants in the treatment of diabetes: a systematic review Electronic Physician. 8(1): 1832–1842.
Lorenzati, Bartolomeo Chiara Zucco, Sara Miglietta, Federico Lamberti, and Graziella Bruno (2010). Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action Pharmaceuticals (Basel). 3(9): 3005–3020.
Luzi L, Pozza G, (1997). Glibenclamide: an old drug with a novel mechanism of action? Acta Diabetol. 34(4):239-44.
Maureen J. Charron, Ellen B. Katz, Ann Louise Olson, (1999). GLUT4 gene regulation and manipulation. The Journal of Biological Chemistry. 274: 3253-3256.
Natali A., Ferrannini E., (2006). Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: A systematic review Diabetologia. 49: 434-441.

Okey A. Ojiako, Paul C. Chikezie, and Agomuo C. Ogbuji, (2016). Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations. J Tradit Complement Med. 6(2): 184–192.
Rachael Rettner, (2018). The 5 'New' Types of Diabetes, Explained. Senior Writer, life science.
Said S Moselhy, IH Kamal, Taha A Kumosani, EA Huwait, (2016). Possible inhibition of hydroxyl methyl glutaryl CoA reductase activity by nicotinic acid and ergosterol. Afr Health Sci. 16(1): 319–324.
Seth G. Thacker, Xavier Rousset, Safi ya Esmail (2015). Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice. Journal of lipid research. 56: 1282-1295.
Simeon I. Taylor, (1999). The Online Metabolic and Molecular Bases of Inherited Disease Insulin Action, Insulin Resistance, and Type 2 Diabetes Mellitus) McGraw-Hill Medical Products. Chapter 68: 1945-7197
Stanely Mainzen Prince, Venugopal P. Menon, (2001). Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytotherapy Research. 15: 213-218.
Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, (2006). Adiponectin and adiponectin receptors in insulin resistance, diabetes, and metabolic syndrome. J Clin Invest. 116(7): 1784–1792.
Tun, Nyo Nyo; Ganesan Arunagirinathan, Sunil K Munshi, and Joseph M Pappachan (2017) Diabetes mellitus and stroke: A clinical update. World Journal Diabetes. 8(6): 235–248
Published
2019-10-31
Section
Nutrition/Natural Product and Drug Development