Effects of Diets Containing Seeds of Soybean (Glycine max) on Healing of Acetic Acid Induced Gastric Ulcers in Rats

  • Adetunji Olugbesan
  • Adeola T Salami
  • Adeola Odukanmi
  • Tosan Omayone
  • Tolulope Iyiola
  • Samuel Babafemi Olaleye


The effect of soya bean incorporation into rat diet on healing of experimental gastric ulcers was investigated. Seventy-five male rats (120-140g; n=5) were grouped: group A (control), B (ulcer untreated), C–D were (25%, 50% and 75% raw SB diet respectively) fed for six weeks respectively.  Thereafter, gastric ulcer was induced using acetic acid and feeding continued till the end of the experiment. Daily body weights were monitored, Gastric basal acid secretion, ulcer score and histological evaluations were carried out on days 3, 7 and 10 post ulcer induction. Results were subjected to one-way ANOVA analysis, presented as Mean±SEM and p=0.05 were significant. Body weights of SB diets fed rats were significantly increased compared with ulcer alone all through the experiment. Basal acid output were significantly reduced in 50% and 75% SB diet (days 3 and 10) and by day 7 in 75% SB diet compared with ulcer untreated group. The 75% SB diet had the highest healing rate of 68% and 92.1% while 25% SB diet had the least healing rate of 50% and 47.5% on days 3 and 10 respectively. There were no visible lesions but moderate preponderance of mucous cells in gastric tunics were observed in both the 50% and 75% SB diet. Soya bean diet may be beneficial in peptic ulcer management.


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Nutrition/Natural Product and Drug Development